We are profiling epigenetic changes that coincide with tumor progression in the KP autochthonous mouse model of lung adenocarcinoma. To do this, we are performing bulk and single cell assay for transposase accessible chromatin using sequencing (ATAC-sequencing) to profile the chromatin state in this model. We aim to study transcriptional and epigenetic mechanisms that drive tumor progression and metastasis in the KP model.