Recent Papers:
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Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Pancreatic cancer-restricted cryptic antigens are targets for T cell recognition
Ely ZA, Kulstad ZJ, Gunaydin G, Addepalli S, Verzani EK, Casarrubios M, Clauser KR, Wang X, Lippincott IE, Louvet C, Schmitt T, Kapner KS, Agus MP, Hennessey CJ, Cleary JM, Hadrup SR, Klaeger S, Su J, Jaeger AM, Wolpin BM, Raghavan S, Smith EL, Greenberg PD, Aguirre AJ, Abelin JG, Carr SA, Jacks T, Freed-Pastor WA. Science. 2025 May 8;388(6747):eadk3487. doi: 10.1126/science.adk3487. Epub 2025 May 8. PMID: 40339010 Free PMC article. -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Spatially resolved analysis of pancreatc cancer identifies therapy-associated remodeling of the tumor microenvironment
Shiau C, Cao J, Gong D, Gregory MT, Caldwell NJ, Yin X, Cho JW, Wang PL, Su J, Wang S, Reeves JW, Kim TK, Kim Y, Guo JA, Lester NA, Bae JW, Zhao R, Schurman N, Barth JL, Ganci ML, Weissleder R, Jacks T, Qadan M, Hong TS, Wo JY, Roberts H, Beechem JM, Castillo CF, Mino-Kenudson M, Ting DT, Hemberg M, Hwang WL. Nat Genet. 2024 Nov;56(11):2466-2478. doi: 10.1038/s41588-024-01890-9. Epub 2024 Sep 3. PMID: 39227743 -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis
Jones MG, Sun D, Min KHJ, Colgan WN, Tian L, Weir JA, Chen VZ, Koblan LW, Yost KE, Mathey-Andrews N, Russell AJC, Stickels RR, Balderrama KS, Rideout WM 3rd, Chang HY, Jacks T, Chen F, Weissman JS, Yosef N, Yang D. bioRxiv [Preprint]. 2024 Oct 24:2024.10.21.619529. doi: 10.1101/2024.10.21.619529. PMID: 39484491 -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778SOX17 enables immune evasion of early colorectal adenomas and cancers
Goto N, Westcott PMK, Goto S, Imada S, Taylor MS, Eng G, Braverman J, Deshpande V, Jacks T, Agudo J, Yilmaz ÖH. Nature. 2024;627(8004):636-645. doi:10.1038/s41586-024-07135-3. Epub 2024 Feb 18. PMID: 38418875. -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Deciphering cell states and genealogies of human human hematopoesis
Weng C, Yu F, Yang D, Poeschla M, Liggett LA, Jones MG, Qiu X, Wahlster L, Caulier A, Hussmann JA, Schnell A, Yost KE, Koblan L, Martin-Rufino JD, Min J, Hammond A, Ssozi D, Bueno R, Mallidi H, Kreso A, Escabi J, Rideout WM 3rd, Jacks T, Hormoz S, van Galen P, Weissman JS, Sankaran VG. Nature. 2024 Mar; 627(8003):389-398. doi: 10.1038/s41586-024-07066-z. epub 2024 Jan 22. PMID:38253266. -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Inhalable point-of-care urinary diagnostic platform
Sci Adv. 2024 Jan 5;10(1):eadj9591. doi: 10.1126/sciadv.adj9591. Epub 2024 Jan 5.PMC10776015. -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
Nat Genet. 2023 Oct;55(10):1686-1695. doi: 10.1038/s41588-023-01499-4. Epub 2023 Sep 14. PMCID: PMC10562252. -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778A prime editor mouse to model a broad spectrum of somatic mutations in vivo
Ely ZA, Mathey-Andrews N, Naranjo S, Gould SI, Mercer KL, Newby GA, Cabana CM, Rideout WM 3rd, Jaramillo GC, Khirallah JM, Holland K, Randolph PB, Freed-Pastor WA, Davis JR, Kulstad Z, Westcott PMK, Lin L, Anzalone AV, Horton BL, Pattada NB, Shanahan SL, Ye Z, Spranger S, Xu Q, Sánchez-Rivera FJ, Liu DR, Jacks T. Nat Biotechnol. 2024 March;42(3): 424-436. doi: 10.1038/s41587-023-01783-y. epub 2023 May 11. PMID: 37169967 -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma
Gaglia G, Burger ML, Ritch CC, Rammos D, Dai Y, Crossland GE, Tavana SZ, Warchol S, Jaeger AM, Naranjo S, Coy S, Nirmal AJ, Krueger R, Lin JR, Pfister H, Sorger PK, Jacks T, Santagata S. Cancer Cell. 2023 May 8;41(5):871-886.e10. doi: 10.1016/j.ccell.2023.03.015. Epub 2023 Apr 13. PMID: 37059105 -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Lung Adenocarcinoma promotion by air pollutants
Hill W, Lim EL, Weeden CE, Lee C, Augustine M, Chen K, Kuan FC, Marongiu F, Evans EJ Jr, Moore DA, Rodrigues FS, Pich O, Bakker B, Cha H, Myers R, van Maldegem F, Boumelha J, Veeriah S, Rowan A, Naceur-Lombardelli C, Karasaki T, Sivakumar M, De S, Caswell DR, Nagano A, Black JRM, Martínez-Ruiz C, Ryu MH, Huff RD, Li S, Favé MJ, Magness A, Suárez-Bonnet A, Priestnall SL, Lüchtenborg M, Lavelle K, Pethick J, Hardy S, McRonald FE, Lin MH, Troccoli CI, Ghosh M, Miller YE, Merrick DT, Keith RL, Al Bakir M, Bailey C, Hill MS, Saal LH, Chen Y, George AM, Abbosh C, Kanu N, Lee SH, McGranahan N, Berg CD, Sasieni P, Houlston R, Turnbull C, Lam S, Awadalla P, Grönroos E, Downward J, Jacks T, Carlsten C, Malanchi I, Hackshaw A, Litchfield K; TRACERx Consortium; DeGregori J, Jamal-Hanjani M, Swanton C. Nature. 2023 Apr;616(7955):159-167. doi: 10.1038/s41586-023-05874-3. Epub 2023 Apr 5. PMID: PMC7614604.