Recent Papers:
-
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Visinity: Visual Spatial Neighborhood Analysis for Multiplexed Tissue Imaging Data
Warchol S, Krueger R, Nirmal AJ, Gaglia G, Jessup J, Ritch CC, Hoffer J, Muhlich J, Burger ML, Jacks T, Santagata S, Sorger PK, Pfister H. EEE Trans Vis Comput Graph. 2023 Jan;29(1):106-116. doi: 10.1109/TVCG.2022.3209378. Epub 2022 Dec 16. PMID: 36170403 -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Multscale profiling of protease activity in cancer
Amini AP, Kirkpatrick JD, Wang CS, Jaeger AM, Su S, Naranjo S, Zhong Q, Cabana CM, Jacks T, Bhatia SN. Nat Commun. 2022 Oct 3;13(1):5745. doi: 10.1038/s41467-022-32988-5. PMID: 36192379 -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A. Nature Genet. 2022 Aug 54(8):1178-1191.doi: 10.1038/s41588-022-01134-8. Epub 2022 Jul 28. PMID: PMC10290535. -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform
Naranjo S, Cabana CM, LaFave LM, Romero R, Shanahan SL, Bhutkar A, Westcott PMK, Schenkel JM, Ghosh A, Liao LZ, Del Priore I, Yang D, Jacks T. Genes Dev. 2022 Aug 1;36(15-16):936-949. doi: 10.1101/gad.349659.122. Epub 2022 Sep 29. PMID: 36175034, -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Deciphering the immunopeptidome in vivo reveals new tumour antigens
Jaeger AM, Stopfer LE, Ahn R, Sanders EA, Sandel DA, Freed-Pastor WA, Rideout WM 3rd, Naranjo S, Fessenden T, Nguyen KB, Winter PS, Kohn RE, Westcott PMK, Schenkel JM, Shanahan SL, Shalek AK, Spranger S, White FM, Jacks T. Jul;607(7917):149-155. doi: 10.1038/s41586-022-04839-2. Epub 2022 Jun 15. PMID: PMC9945857. -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
Yang D, Jones MG, Naranjo S, Rideout WM 3rd, Min KHJ, Ho R, Wu W, Replogle JM, Page JL, Quinn JJ, Horns F, Qiu X, Chen MZ, Freed-Pastor WA, McGinnis CS, Patterson DM, Gartner ZJ, Chow ED, Bivona TG, Chan MM, Yosef N, Jacks T, Weissman JS. PMID: PMC9452598 . -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities
Shi DD, Guo JA, Hoffman HI, Su J, Mino-Kenudson M, Barth JL, Schenkel JM, Loeffler JS, Shih HA, Hong TS, Wo JY, Aguirre AJ, Jacks T, Zheng L, Wen PY, Wang TC, Hwang WL. PMID: PMC9516432. Review. -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells
Patel RS, Romero R, Watson EV, Liang AC, Burger M, Westcott PMK, Mercer KL, Bronson RT, Wooten EC, Bhutkar A, Jacks T, Elledge SJ. 2022 Jan 11;13(1):256. doi: 10.1038/s41467-021-27731-5. PMID: 35017504. -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Spatial genomics enables multi-modal study of clonal heterogeneity in tissues
Zhao T, Chiang ZD, Morriss JW, LaFave LM, Murray EM, Del Priore I, Meli K, Lareau CA, Nadaf NM, Li J, Earl AS, Macosko EZ, Jacks T, Buenrostro JD, Chen F. Nature. 2022 Jan;601(7891):85-91. doi: 10.1038/s41586-021-04217-4. Epub 2021 Dec 15. PMID: 34912115. -
Clonal hematopoiesis in lung adenocarcinoma pathogenesis.
Parisi T, Santibanez Ocampo B, Adelman J, Cai Y, McConkey M, Gibson CJ, Ebert BL, Miller P, Jacks T. JCI Insight. 2026 May 8;11(9):e203981. doi: 10.1172/jci.insight.203981. eCollection 2026 May 8.PMID: 42100867Free PMC article.
Intrinsic electrical activity drives small-cell lung cancer progression
Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12.PMID: 39939778Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
Raghavan S, Winter PS, Navia AW, Williams HL, DenAdel A, Lowder KE, Galvez-Reyes J, Kalekar RL, Mulugeta N, Kapner KS, Raghavan MS, Borah AA, Liu N, Väyrynen SA, Costa AD, Ng RWS, Wang J, Hill EK, Ragon DY, Brais LK, Jaeger AM, Spurr LF, Li YY, Cherniack AD, Booker MA, Cohen EF, Tolstorukov MY, Wakiro I, Rotem A, Johnson BE, McFarland JM, Sicinska ET, Jacks TE, Sullivan RJ, Shapiro GI, Clancy TE, Perez K, Rubinson DA, Ng K, Cleary JM, Crawford L, Manalis SR, Nowak JA, Wolpin BM, Hahn WC, Aguirre AJ, Shalek AK. Cell. 2021 Dec 9;184(25):6119-6137.e26. doi: 10.1016/j.cell.2021.11.017. PMID: 34890551.