Recent Papers:
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Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer
Westcott PMK, Sacks NJ, Schenkel JM, Ely ZA, Smith O, Hauck H, Jaeger AM, Zhang D, Backlund CM, Beytagh MC, Patten JJ, Elbashir R, Eng G, Irvine DJ, Yilmaz OH, Jacks T. Nat Cancer. 2021 Oct;2(10):1071-1085. doi: 10.1038/s43018-021-00247-z. PMID:34738089. -
Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice
Hamza B, Miller AB, Meier L, Stockslager M, Ng SR, King EM, Lin L, DeGouveia KL, Mulugeta N, Calistri NL, Strouf H, Bray C, Rodriguez F, Freed-Pastor WA, Chin CR, Jaramillo GC, Burger ML, Weinberg RA, Shalek AK, Jacks T, Manalis SR. Nat Commun. 2021 Sep 28;12(1):5680. doi: 10.1038/s41467-021-25917-5. PMID: 34584084. -
SMARCA4 inactivation promotes lineage-specific transformation and early metatatic features in the lung
Concepcion CP, Ma S, LaFave LM, Bhutkar A, Liu M, DeAngelo LP, Kim JY, Del Priore I, Schoenfeld AJ, Miller M, Kartha VK, Westcott PMK, Sanchez-Rivera FJ, Meli K, Gupta M, Bronson RT, Riely GJ, Rekhtman N, Rudin CM, Kim CF, Regev A, Buenrostro JD, Jacks T. Cancer Discov. 2021 Sep 24:candisc.0248.2021. doi: 10.1158/2159-8290.CD-21-0248. Online ahead of print. PMID: 34561242. -
Antigen dominance hierarchies shape TCR1+ progenitor CD8 T cell phenotypes in tumors
Burger ML, Cruz AM, Crossland GE, Gaglia G, Ritch CC, Blatt SE, Bhutkar A, Canner D, Kienka T, Tavana SZ, Barandiaran AL, Garmilla A, Schenkel JM, Hillman M, de Los Rios Kobara I, Li A, Jaeger AM, Hwang WL, Westcott PMK, Manos MP, Holovatska MM, Hodi FS, Regev A, Santagata S, Jacks T. Cell. 2021 Sep 16;184(19):4996-5014.e26. doi: 10.1016/j.cell.2021.08.020. PMID: 34534464. -
Conventional type 1 dendric cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lumph nodes
Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan SL, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, Park JK, Burger ML, Rozenblatt-Rosen O, Cong L, Pauken KE, Regev A, Jacks T. 54(10):2338-2353.e6doi: 10.1016/j.immuni.2021.08.026. PMID:34534439. -
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
Genshaft AS, Ziegler CGK, Tzouanas CN, Mead BE, Jaeger AM, Navia AW, King RP, Mana MD, Huang S, Mitsialis V, Snapper SB, Yilmaz OH, Jacks T, Van Humbeck JF, Shalek AK. Nat Commun. 2021 Aug 17;12(1):5361. doi: 10.1038/s41467-021-25279-y. PMID: 34404785. -
Rif-Mycl gene fusion drives tumorigenesis and metastasis in a mouse model of small cell lung cancer
Ciampricotti M, Karakousi T, Richards AL Quintanal-Villalonga A, Karatza A, Caeser R, Costa EA, Allaj V, Manoj P, Spainhower KB, Kombak FE, Sanchez-Rivera FJ, Jaspers JE, Zavitsanou AM, Maddalo D, Ventura A, Rideout WM, Akama-Garren EH, Jacks T, Donoghue MTA, Sen T, Oliver TG, Poirier JT, Papagiannakopoulos T, Rudin CM. Cancer Discov. 2021 Aug 3:candisc.0441.2021. doi: 10.1158/2159-8290.CD-21-0441. Online ahead of print. PMID: 34344693. -
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer.
Freed-Pastor WA, Lambert LJ, Ely ZA, Pattada NB, Bhutkar A, Eng G, Mercer KL, Garcia AP, Lin L, Rideout WM 3rd, Hwang WL, Schenkel JM, Jaeger AM, Bronson RT, Westcott PMK, Hether TD, Divakar P, Reeves JW, Deshpande V, Delorey T, Phillips D, Yilmaz OH, Regev A, Jacks T. Cancer Cell. 2021 Oct 11;39(10):1342-1360.e14. doi: 10.1016/j.ccell.2021.07.007. Epub 2021 Aug 5. PMID: 34358448. -
The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain
Hajal C, Shin Y, Li L, Serrano JC, Jacks T, Kamm RD. Sci Adv. 2021. June 23;7(26):eabg8139. doi: 10.1126/sciadv.abg8139. PMCID:34162553. -
Protocol for single-cell ATAC-sequencing using combinatorial indexing
Del Priore I, Ma S, Strecker J, Jacks T, LaFave LM*, Buenrostro JD* Jun 3;2(2):100583. doi: 10.1016/j.xpro.2021.100583. eCollection 2021 Jun 18. PMID: 34142101