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Jacks Lab

Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

The Jacks Lab

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    • Engineering hypermutant cancer models
    • Modeling cancer using CRISPR/Cas9 system
    • Epigenetic changes during lung cancer progression
    • Anti-oxidant response in lung tumorigenesis
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MMHCC Mouse Repository

The following mouse strains are available for free from the MMHCC Mouse Repository

Rb Null

KrasLA1

KrasLA2

Kras LSL G12D (Conditional G12D allele)

ROSA-Cre ER

ROSA26-pCAGGc-LSL-Luciferase (unpublished)

p53 CONDITIONAL point mutants - 129 background

p53 LSL R172H

p53 LSL R270H

p53 GERMLINE point mutants - 129 background

p53 R172H

p53 R270H

p53 floxed (Anton Berns)

NF1 knock out (Luis Parada)

B6 background

129 background

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